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ÇiÄŸdem Gelegen, PhD.
Completed
Metabolic expenditure, neurodevelopment, and weight gain into early childhood after fetal growth restriction
Placental insufficiency is a serious complication of pregnancy and an important cause of foetal growth restriction (FGR). Premature babies born with FGR adopt strategies to minimize energy expenditure. In this study, using scalp EEG, we tested whether new-borns with FGR have reduced post-synaptic activity, with a focus on temporal theta transients, which are the earliest form of neural activity generated in the primary auditory cortex.
The plot above shows an example of temporal transient activity and their density as a function of age in FGR and control babies. On the left side, the upper panel shows an example transient in the time domain, the middle panel shows time frequency decomposition of the transient using Morlet wavelets and the bottom panel shows time domain band pass filtered using Hilber transform to extract transients. The plot on the right side shows how the number of transients per minute in controls and FGR babies changes as they age.